Gene Information
Gene NameHLA-DPA1
OrganismHomo sapiens (Human)
Gene Length260
Protein NamesHLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)
Target NameNA
Target TypeNA
Gene Age3 ( ENSG00000168384 )
3 ( ENSG00000206291 )
3 ( ENSG00000224103 )
3 ( ENSG00000228163 )
3 ( ENSG00000229685 )
168 ( ENSG00000231389 )
3 ( ENSG00000235844 )
3 ( ENSG00000236177 )
Evolutionary StageVertebrata
AlphaFoldDBP20036
Gene CardHLA-DPA1
Uniprot IDP20036
PfamPF07654; PF00993
In ASDno
Allosteric Predictionno (-0.105206152)
Ortholog in AnimalsAlpaca_ HLA-DPA1 ( ortholog_one2one )
Rat_ AABR07044416.1 ( ortholog_one2one )
OhnologsNA
ParalogsHLA-DPB1, HLA-DMB, HLA-DOA, HLA-DQA1, HLA-DQA2, HLA-DOB, HLA-DRA, HLA-DRB5, HLA-DRB1, B2M, HLA-DQB1, HLA-DQB2, HLA-DMA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LQZ  (X-ray  3.25A  )  4P4K  (X-ray  2.80A  )  4P4R  (X-ray  3.00A  )  4P57  (X-ray  2.60A  )  4P5K  (X-ray  2.59A  )  4P5M  (X-ray  1.70A  ) 
DBSNP rs386699859  rs1126533  rs1126534  rs2308907  rs1042175  rs2308910  rs2308912  rs2308911  rs36013091  rs72558171  rs1042178  rs41543112  rs2308917  rs61759929  rs41559316  rs1126542  rs41562016  rs1042190  rs2308930  rs1042308  rs17509489  rs1126769 
Subcellular location [CC]Cell membrane;
Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane;
Single-pass type I membrane protein. Endosome membrane;
Single-pass type I membrane protein. Lysosome membrane;
Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Mouse PG classificationNA
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