| Gene Information | |
|---|---|
| Gene Name | MTA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 715 |
| Protein Names | Metastasis-associated protein MTA1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000182979 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13330 |
| Gene Card | MTA1 |
| Uniprot ID | Q13330 |
| Pfam | PF01426; PF01448; PF00320; PF17226; PF00249 |
| In ASD | no |
| Allosteric Prediction | yes (0.619879685) |
| Ortholog in Animals | Alpaca_ MTA1 ( ortholog_one2one ) Dog_ TEDC1 ( ortholog_one2one ) GuineaPig_ MTA1 ( ortholog_one2one ) Macaque_ MTA1 ( ortholog_one2one ) Mouse_ Mta1 ( ortholog_one2one ) Pig_ MTA1 ( ortholog_one2one ) Rat_ Mta1 ( ortholog_one2one ) |
| Ohnologs | MTA3, MTA2 |
| Paralogs | MTA2, MTA3, MIER3, MIER2, MIER1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis. {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:24970816}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4BKX (X-ray 3.00A ) 4PBY (X-ray 2.50A ) 4PBZ (X-ray 2.15A ) 4PC0 (X-ray 2.50A ) 5FXY (X-ray 3.20A ) 5ICN (X-ray 3.30A ) 6G16 (X-ray 2.80A ) 6ZRC (X-ray 2.60A ) 6ZRD (X-ray 2.50A ) 7AO8 (EM 4.50A ) 7AO9 (EM 6.10A ) 7AOA (EM 19.40A ) |
| DBSNP | rs4983413 rs13707 |
| Subcellular location [CC] | [Isoform Short]: Cytoplasm.; [Isoform Long]: Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Localization at the nuclear envelope is TPR-dependent. |
| Mouse PG classification | NA |
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