| Gene Information | |
|---|---|
| Gene Name | EIF4ENIF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 985 |
| Protein Names | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000184708 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NRA8 |
| Gene Card | EIF4ENIF1 |
| Uniprot ID | Q9NRA8 |
| Pfam | PF10477 |
| In ASD | no |
| Allosteric Prediction | no (-0.908979787) |
| Ortholog in Animals | Alpaca_ EIF4ENIF1 ( ortholog_one2one ) Alpaca_ EIF4ENIF1 ( ortholog_one2many ) Dog_ EIF4ENIF1 ( ortholog_one2one ) GuineaPig_ EIF4ENIF1 ( ortholog_one2one ) Macaque_ EIF4ENIF1 ( ortholog_one2one ) Mouse_ Eif4enif1 ( ortholog_one2one ) Pig_ EIF4ENIF1 ( ortholog_one2one ) Rat_ Eif4enif1 ( ortholog_one2one ) Rabbit_ EIF4ENIF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10856257}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ANR (X-ray 2.10A ) 6F9W (X-ray 2.62A ) 6X2R (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:23991149, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:32354837}. Cytoplasm {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:28216671}. Nucleus {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:28216671}. Nucleus, PML body {ECO:0000269|PubMed:22090346}. Nucleus speckle {ECO:0000269|PubMed:22090346}. Note=Predominantly cytoplasmic (PubMed:10856257). Mainly localizes to processing bodies (P-bodies) (PubMed:16157702). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:10856257). Localization to nuclear foci and speckles requires active transcription (PubMed:22090346). {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22090346}. |
| Mouse PG classification | NA |
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