| Gene Information | |
|---|---|
| Gene Name | KIAA1112 |
| Organism | Homo sapiens (Human) |
| Gene Length | 690 |
| Protein Names | Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NR80 |
| Gene Card | ARHGEF4 |
| Uniprot ID | Q9NR80 |
| Pfam | PF00169; PF00621; PF00018 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:19893577}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DX1 (X-ray 2.36A ) 2PZ1 (X-ray 2.25A ) 3NMX (X-ray 2.30A ) 3NMZ (X-ray 3.01A ) |
| DBSNP | rs10188052 |
| Subcellular location [CC] | [Isoform 3]: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}. |
| Mouse PG classification | NA |
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