| Gene Information | |
|---|---|
| Gene Name | CYP2A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 494 |
| Protein Names | Cytochrome P450 2A6 (EC 1.14.14.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I)) |
| Target Name | cytochrome p450 2a6 |
| Target Type | Successful target |
| Gene Age | 12 ( ENSG00000255974 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P11509 |
| Gene Card | CYP2A6 |
| Uniprot ID | P11509 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.584935728) |
| Ortholog in Animals | Dog_ CYP2A13 ( ortholog_many2many ) Dog_ CYP2A7 ( ortholog_many2many ) Mouse_ Cyp2a5 ( ortholog_many2many ) Mouse_ Cyp2a4 ( ortholog_many2many ) Rat_ Cyp2a3 ( ortholog_one2many ) Rabbit_ CYP2A10 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CYP2A7, CYP2A13, CYP2S1, CYP2W1, CYP2D6, CYP2C18, CYP2C9, CYP2C19, CYP2B6, CYP2C8, CYP2U1, CYP2F1, CYP2R1, CYP2E1, CYP2J2 |
| Tissue | liver, brain |
| Tissue Specificity | Liver. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z10 (X-ray 1.90A ) 1Z11 (X-ray 2.05A ) 2FDU (X-ray 1.85A ) 2FDV (X-ray 1.65A ) 2FDW (X-ray 2.05A ) 2FDY (X-ray 1.95A ) 3EBS (X-ray 2.15A ) 3T3Q (X-ray 2.10A ) 3T3R (X-ray 2.40A ) 4EJJ (X-ray 2.30A ) 4RUI (X-ray 2.61A ) |
| DBSNP | rs28399434 rs28399435 rs72549435 rs28399440 rs4986891 rs4986891 rs59552350 rs1801272 rs199916117 rs56256500 rs56256500 rs28399447 rs2644906 rs4997557 rs28399454 rs1809810 rs28399463 rs8192730 rs143731390 rs5031016 rs6413474 rs5031017 rs28399468 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Mouse PG classification | NA |
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