| Gene Information | |
|---|---|
| Gene Name | KIAA1075 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1409 |
| Protein Names | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q63HR2 |
| Gene Card | TNS2 |
| Uniprot ID | Q63HR2 |
| Pfam | PF08416; PF10409; PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:12470648}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2DKQ (NMR - ) 2KNO (NMR - ) 2L6K (NMR - ) 2LOZ (NMR - ) 3HQC (X-ray 1.80A ) |
| DBSNP | rs11170389 rs11558984 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:22019427}. Cell membrane {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:30092354}; Peripheral membrane protein {ECO:0000269|PubMed:11792844}; Cytoplasmic side {ECO:0000269|PubMed:11792844}. Cytoplasm {ECO:0000269|PubMed:22019427, ECO:0000269|PubMed:25101860}. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427, PubMed:25101860). Localizes to both focal adhesions and fibrillar adhesions but is found mainly in focal adhesions (PubMed:20069572). Enriched in dynamic focal adhesions at the leading edge of the cell and is found only rarely in fibrillar adhesions on the ventral surface of cells (PubMed:20069572). {ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:22019427, ECO:0000269|PubMed:25101860}. |
| Mouse PG classification | NA |
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