Gene Information
Gene NameHSD17B1
OrganismHomo sapiens (Human)
Gene Length328
Protein Names17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)
Target Nameestradiol 17 beta-dehydrogenase 1
Target TypeClinical trial target
Gene Age454 ( ENSG00000108786 )
Evolutionary StageCellular_organisms
AlphaFoldDBP14061
Gene CardHSD17B1
Uniprot IDP14061
PfamPF00106
In ASDno
Allosteric Predictionyes (0.005630154)
Ortholog in AnimalsAlpaca_ HSD17B1 ( ortholog_one2one )
Dog_ HSD17B1 ( ortholog_one2one )
GuineaPig_ HSD17B1 ( ortholog_one2one )
Macaque_ HSD17B1 ( ortholog_one2one )
Mouse_ Hsd17b1 ( ortholog_one2one )
Pig_ HSD17B1 ( ortholog_one2one )
Rat_ Hsd17b1 ( ortholog_one2one )
OhnologsNA
ParalogsSDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, RDH10, HSD17B10, HSD17B3, HSD17B6
Tissueplacenta
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1A27  (X-ray  1.90A  1BHS  (X-ray  2.20A  1DHT  (X-ray  2.24A  1EQU  (X-ray  3.00A  1FDS  (X-ray  1.70A  1FDT  (X-ray  2.20A  1FDU  (X-ray  2.70A  1FDV  (X-ray  3.10A  1FDW  (X-ray  2.70A  1I5R  (X-ray  1.60A  1IOL  (X-ray  2.30A  1JTV  (X-ray  1.54A  1QYV  (X-ray  1.81A  1QYW  (X-ray  1.63A  1QYX  (X-ray  1.89A  3DEY  (X-ray  1.70A  3DHE  (X-ray  2.30A  3HB4  (X-ray  2.21A  3HB5  (X-ray  2.00A  3KLM  (X-ray  1.70A  3KLP  (X-ray  2.50A  3KM0  (X-ray  2.30A  6CGC  (X-ray  2.10A  6CGE  (X-ray  2.20A  6DTP  (X-ray  2.00A  6MNC  (X-ray  2.40A  6MNE  (X-ray  1.86A 
DBSNP rs147402365  rs605059 
Subcellular location [CC]Cytoplasm.
Mouse PG classificationNA
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