| Gene Information | |
|---|---|
| Gene Name | CYP1A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 516 |
| Protein Names | Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) |
| Target Name | cytochrome p450 1a2 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000140505 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P05177 |
| Gene Card | CYP1A2 |
| Uniprot ID | P05177 |
| Pfam | PF00067 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000374783) |
| Ortholog in Animals | Alpaca_ CYP1A2 ( ortholog_one2one ) Dog_ CYP1A2 ( ortholog_one2one ) GuineaPig_ CYP1A2 ( ortholog_one2one ) Macaque_ CYP1A2 ( ortholog_one2one ) Mouse_ Cyp1a2 ( ortholog_one2one ) Pig_ CYP1A2 ( ortholog_one2one ) Rat_ Cyp1a2 ( ortholog_one2one ) Rabbit_ CYP1A2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CYP1A1, CYP1B1 |
| Tissue | liver, brain |
| Tissue Specificity | Liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HI4 (X-ray 1.95A ) |
| DBSNP | rs17861152 rs56160784 rs72547511 rs45565238 rs138652540 rs34067076 rs45442197 rs72547512 rs72547513 rs45540640 rs758748797 rs45468096 rs17861157 rs35796837 rs28399418 rs56276455 rs72547515 rs72547516 rs55889066 rs28399424 rs45486893 rs72547517 rs34151816 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein. |
| Mouse PG classification | NA |
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