| Gene Information | |
|---|---|
| Gene Name | GZMH |
| Organism | Homo sapiens (Human) |
| Gene Length | 246 |
| Protein Names | Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100450 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20718 |
| Gene Card | GZMH |
| Uniprot ID | P20718 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.136560808) |
| Ortholog in Animals | Mouse_ Gzmf ( ortholog_one2many ) Mouse_ Gzme ( ortholog_one2many ) Mouse_ Gzmd ( ortholog_one2many ) Mouse_ Gzmb ( ortholog_one2many ) Mouse_ Gzmc ( ortholog_one2many ) Mouse_ Gzmg ( ortholog_one2many ) Mouse_ Gzmn ( ortholog_one2many ) Pig_ GZMH ( ortholog_one2one ) Rat_ Gzmbl2 ( ortholog_one2many ) Rat_ Gzmn ( ortholog_one2many ) Rat_ AABR07018028.1 ( ortholog_one2many ) Rat_ Gzmf ( ortholog_one2many ) Rat_ Gzmbl1 ( ortholog_one2many ) Rat_ Gzmc ( ortholog_one2many ) Rabbit_ GZMH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GZMB, CTSG, CMA1, AZU1, KLK13, KLK6 |
| Tissue | whole.blood |
| Tissue Specificity | Constitutively expressed in NK cells. {ECO:0000269|PubMed:23269243}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3TJU (X-ray 2.70A ) 3TJV (X-ray 2.40A ) 3TK9 (X-ray 2.20A ) 4GAW (X-ray 3.00A ) |
| DBSNP | rs20545 |
| Subcellular location [CC] | Cytolytic granule {ECO:0000269|PubMed:23269243}. |
| Mouse PG classification | NA |
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