| Gene Information | |
|---|---|
| Gene Name | KIAA1007 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2376 |
| Protein Names | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | A5YKK6 |
| Gene Card | CNOT1 |
| Uniprot ID | A5YKK6 |
| Pfam | PF16415; PF16418; PF16417; PF12842; PF04054 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. {ECO:0000269|PubMed:10637334}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.019637(Rat);0.062429(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4C0D (X-ray 3.20A ) 4CQO (X-ray 2.80A ) 4CRU (X-ray 1.65A ) 4CRV (X-ray 2.05A ) 4CRW (X-ray 1.75A ) 4CT4 (X-ray 2.30A ) 4CT6 (X-ray 2.10A ) 4CT7 (X-ray 1.90A ) 4GMJ (X-ray 2.70A ) 4GML (X-ray 2.90A ) 4J8S (X-ray 1.55A ) 5ANR (X-ray 2.10A ) 5FU6 (X-ray 2.90A ) 5FU7 (X-ray 3.10A ) 5ONA (X-ray 2.70A ) 7VOI (X-ray 4.38A ) |
| DBSNP | rs1567420855 rs1567417422 rs17854028 rs2040438229 rs1038725612 rs1567396193 rs1184460054 |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:21976065}. Nucleus {ECO:0000305|PubMed:21976065}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q6ZQ08}. |
| Mouse PG classification | NA |
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