| Gene Information | |
|---|---|
| Gene Name | AOC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 756 |
| Protein Names | Retina-specific copper amine oxidase (RAO) (EC 1.4.3.21) (Amine oxidase [copper-containing]) (Semicarbazide-sensitive amine oxidase) (SSAO) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000131480 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O75106 |
| Gene Card | AOC2 |
| Uniprot ID | O75106 |
| Pfam | PF01179; PF02727; PF02728 |
| In ASD | no |
| Allosteric Prediction | no (-0.222019974) |
| Ortholog in Animals | Alpaca_ AOC2 ( ortholog_one2many ) Dog_ AOC2 ( ortholog_one2one ) Macaque_ AOC2 ( ortholog_one2one ) Mouse_ Aoc2 ( ortholog_one2one ) Pig_ AOC2 ( ortholog_one2one ) Rabbit_ AOC2 ( ortholog_one2one ) |
| Ohnologs | AOC1 |
| Paralogs | AOC3, AOC1 |
| Tissue | bone.marrow |
| Tissue Specificity | Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis. {ECO:0000269|PubMed:12755418, ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34230945 rs34435306 rs35833794 rs35508987 rs34351794 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19588076}; Peripheral membrane protein {ECO:0000269|PubMed:19588076}. Note=Present on the surface of the cells. {ECO:0000269|PubMed:19588076}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19588076}. Note=Either not translocated to the plasma membrane or below detection level. {ECO:0000269|PubMed:19588076}. |
| Mouse PG classification | NA |
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