| Gene Information | |
|---|---|
| Gene Name | IL17A |
| Organism | Homo sapiens (Human) |
| Gene Length | 155 |
| Protein Names | Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8) |
| Target Name | interleukin-17 |
| Target Type | Successful target |
| Gene Age | 244 ( ENSG00000112115 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16552 |
| Gene Card | IL17A |
| Uniprot ID | Q16552 |
| Pfam | PF06083 |
| In ASD | no |
| Allosteric Prediction | yes (0.042860982) |
| Ortholog in Animals | Alpaca_ IL17A ( ortholog_one2one ) GuineaPig_ IL17A ( ortholog_one2one ) Macaque_ IL17A ( ortholog_one2one ) Mouse_ Il17a ( ortholog_one2one ) Pig_ IL17A ( ortholog_one2one ) Rat_ Il17a ( ortholog_one2one ) Rabbit_ IL17A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL17F, IL17D, IL17B, IL17C, IL25 |
| Tissue | NA |
| Tissue Specificity | Expressed in memory Th17 cells (at protein level). {ECO:0000269|PubMed:17763419}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VXS (X-ray 2.63A ) 4HR9 (X-ray 2.48A ) 4HSA (X-ray 3.15A ) 4QHU (X-ray 2.20A ) 5HHV (X-ray 2.20A ) 5HHX (X-ray 3.00A ) 5HI3 (X-ray 2.15A ) 5HI4 (X-ray 1.80A ) 5HI5 (X-ray 1.80A ) 5N7W (X-ray 1.96A ) 5N92 (X-ray 2.30A ) 5NAN (X-ray 3.30A ) 5VB9 (X-ray 1.70A ) 6WIO (X-ray 2.17A ) 6WIR (X-ray 2.96A ) 7AMA (X-ray 2.48A ) 7AMG (X-ray 3.18A ) 7UWM (EM 2.50A ) 7UWN (EM 3.01A ) 7WKX (X-ray 2.81A ) 8DYF (X-ray 2.02A ) 8DYG (X-ray 1.49A ) 8DYH (X-ray 1.94A ) 8DYI (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17763419, ECO:0000269|PubMed:8676080}. |
| Mouse PG classification | NA |
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