| Gene Information | |
|---|---|
| Gene Name | ATP6V0A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 837 |
| Protein Names | V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) |
| Target Name | v-atpase subunits |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000033627 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q93050 |
| Gene Card | ATP6V0A1 |
| Uniprot ID | Q93050 |
| Pfam | PF01496 |
| In ASD | no |
| Allosteric Prediction | yes (0.367040428) |
| Ortholog in Animals | Alpaca_ ATP6V0A1 ( ortholog_one2one ) Dog_ ATP6V0A1 ( ortholog_one2one ) GuineaPig_ ATP6V0A1 ( ortholog_one2one ) Macaque_ ATP6V0A1 ( ortholog_one2one ) Mouse_ Atp6v0a1 ( ortholog_one2one ) Pig_ ATP6V0A1 ( ortholog_one2one ) Rat_ Atp6v0a1 ( ortholog_one2one ) Rabbit_ ATP6V0A1 ( ortholog_one2one ) |
| Ohnologs | ATP6V0A4 |
| Paralogs | TCIRG1, ATP6V0A2, ATP6V0A4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.298836(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WLW (EM 3.00A ) 6WM2 (EM 3.10A ) 6WM3 (EM 3.40A ) 6WM4 (EM 3.60A ) 7U4T (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |