| Gene Information | |
|---|---|
| Gene Name | NUDT21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 227 |
| Protein Names | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000167005 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43809 |
| Gene Card | NUDT21 |
| Uniprot ID | O43809 |
| Pfam | PF13869 |
| In ASD | no |
| Allosteric Prediction | no (-0.957249634) |
| Ortholog in Animals | Alpaca_ NUDT21 ( ortholog_one2one ) Dog_ NUDT21 ( ortholog_one2one ) GuineaPig_ NUDT21 ( ortholog_one2one ) Macaque_ NUDT21 ( ortholog_one2one ) Mouse_ Nudt21 ( ortholog_one2one ) Rat_ Nudt21 ( ortholog_one2one ) Rabbit_ NUDT21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:17098938}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.093917(Rat);0.009091(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CL3 (X-ray 1.90A ) 2J8Q (X-ray 2.30A ) 3BAP (X-ray 1.85A ) 3BHO (X-ray 1.80A ) 3MDG (X-ray 2.22A ) 3MDI (X-ray 2.07A ) 3N9U (X-ray 1.92A ) 3P5T (X-ray 2.70A ) 3P6Y (X-ray 2.90A ) 3Q2S (X-ray 2.90A ) 3Q2T (X-ray 3.06A ) 5R4P (X-ray 1.78A ) 5R4Q (X-ray 1.49A ) 5R4R (X-ray 1.50A ) 5R4S (X-ray 1.61A ) 5R4T (X-ray 1.68A ) 5R4U (X-ray 1.92A ) 5R64 (X-ray 1.84A ) 5R65 (X-ray 2.28A ) 5R66 (X-ray 2.02A ) 5R67 (X-ray 1.52A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Cytoplasm {ECO:0000269|PubMed:19864460}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460}. |
| Mouse PG classification | NA |
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