| Gene Information | |
|---|---|
| Gene Name | COL25A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 654 |
| Protein Names | Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000188517 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BXS0 |
| Gene Card | COL25A1 |
| Uniprot ID | Q9BXS0 |
| Pfam | PF01391 |
| In ASD | no |
| Allosteric Prediction | no (-0.619625615) |
| Ortholog in Animals | Alpaca_ COL25A1 ( ortholog_one2one ) Dog_ COL25A1 ( ortholog_one2one ) GuineaPig_ COL25A1 ( ortholog_one2one ) Macaque_ COL25A1 ( ortholog_one2one ) Mouse_ Col25a1 ( ortholog_one2one ) Pig_ COL25A1 ( ortholog_one2one ) Rat_ Col25a1 ( ortholog_one2one ) Rabbit_ COL25A1 ( ortholog_one2one ) |
| Ohnologs | COL23A1 |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL2A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | adipose.tissue, testis |
| Tissue Specificity | Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269|PubMed:11927537}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs780209390 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted. |
| Mouse PG classification | LPG |
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