Gene Information
Gene NamePLA2G7
OrganismHomo sapiens (Human)
Gene Length441
Protein NamesPlatelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)
Target Nameplatelet-activating factor acetylhydrolase
Target TypeClinical trial target
Gene Age1292 ( ENSG00000146070 )
Evolutionary StageEukaryota
AlphaFoldDBQ13093
Gene CardPLA2G7
Uniprot IDQ13093
PfamPF03403
In ASDno
Allosteric Predictionyes (0.705546067)
Ortholog in AnimalsAlpaca_ PLA2G7 ( ortholog_one2one )
Dog_ PLA2G7 ( ortholog_one2one )
GuineaPig_ PLA2G7 ( ortholog_one2one )
Macaque_ PLA2G7 ( ortholog_one2one )
Mouse_ Pla2g7 ( ortholog_one2one )
Pig_ PLA2G7 ( ortholog_one2one )
Rat_ Pla2g7 ( ortholog_one2one )
Rabbit_ PLA2G7 ( ortholog_one2one )
OhnologsPAFAH2
ParalogsPAFAH2
Tissuespleen
Tissue SpecificityPlasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221). {ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3D59  (X-ray  1.50A  )  3D5E  (X-ray  2.10A  )  3F96  (X-ray  2.10A  )  3F97  (X-ray  1.70A  )  3F98  (X-ray  1.70A  )  3F9C  (X-ray  2.30A  )  5I8P  (X-ray  2.37A  )  5I9I  (X-ray  2.70A  )  5JAD  (X-ray  2.05A  )  5JAH  (X-ray  2.06A  )  5JAL  (X-ray  2.06A  )  5JAN  (X-ray  2.12A  )  5JAO  (X-ray  2.06A  )  5JAP  (X-ray  2.46A  )  5JAR  (X-ray  2.11A  )  5JAS  (X-ray  2.06A  )  5JAT  (X-ray  2.04A  )  5JAU  (X-ray  1.95A  )  5LP1  (X-ray  1.91A  )  5LYY  (X-ray  2.17A  )  5LZ2  (X-ray  2.10A  )  5LZ4  (X-ray  2.07A  )  5LZ5  (X-ray  2.05A  )  5LZ7  (X-ray  2.10A  )  5LZ8  (X-ray  2.11A  )  5LZ9  (X-ray  2.06A  )  5YE7  (X-ray  2.31A  )  5YE8  (X-ray  1.85A  )  5YE9  (X-ray  1.88A  )  5YEA  (X-ray  1.80A  )  6M06  (X-ray  2.10A  )  6M07  (X-ray  2.64A  )  6M08  (X-ray  2.19A  ) 
DBSNP rs45521937  rs1805017  rs45454695  rs1805018  rs76863441  rs201256712  rs1051931 
Subcellular location [CC]Secreted, extracellular space {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}. Note=Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756). Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}.
Mouse PG classificationNA
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