| Gene Information | |
|---|---|
| Gene Name | FABP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 132 |
| Protein Names | Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4) |
| Target Name | fatty acid-binding protein 4 |
| Target Type | Patented-recorded target |
| Gene Age | 454 ( ENSG00000170323 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P15090 |
| Gene Card | FABP4 |
| Uniprot ID | P15090 |
| Pfam | PF00061 |
| In ASD | no |
| Allosteric Prediction | no (-0.134933976) |
| Ortholog in Animals | Alpaca_ FABP4 ( ortholog_one2one ) Dog_ FABP4 ( ortholog_one2many ) GuineaPig_ FABP4 ( ortholog_one2one ) Macaque_ FABP4 ( ortholog_one2one ) Mouse_ Fabp4 ( ortholog_one2one ) Pig_ FABP4 ( ortholog_one2one ) Rat_ Fabp4 ( ortholog_one2one ) |
| Ohnologs | FABP3, FABP7 |
| Paralogs | CRABP1, FABP9, FABP5, FABP12, RBP1, PMP2, RBP2, RBP5, RBP7, FABP3, FABP2, FABP6, FABP7, FABP1, CRABP2 |
| Tissue | bone.marrow, breast |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1TOU (X-ray 2.00A ) 1TOW (X-ray 2.00A ) 2HNX (X-ray 1.50A ) 2NNQ (X-ray 1.80A ) 3FR2 (X-ray 2.20A ) 3FR4 (X-ray 2.16A ) 3FR5 (X-ray 2.20A ) 3P6C (X-ray 1.25A ) 3P6D (X-ray 1.06A ) 3P6E (X-ray 1.08A ) 3P6F (X-ray 1.20A ) 3P6G (X-ray 1.20A ) 3P6H (X-ray 1.15A ) 3Q6L (X-ray 1.40A ) 3RZY (X-ray 1.08A ) 4NNS (X-ray 1.53A ) 4NNT (X-ray 1.53A ) 5D45 (X-ray 1.65A ) 5D47 (X-ray 1.70A ) 5D48 (X-ray 1.81A ) 5D4A (X-ray 1.70A ) 5EDB (X-ray 1.18A ) 5EDC (X-ray 1.29A ) 5HZ6 (X-ray 1.14A ) 5HZ8 (X-ray 1.12A ) 5Y0F (X-ray 1.54A ) 5Y0G (X-ray 1.54A ) 5Y0X (X-ray 1.60A ) 5Y12 (X-ray 1.75A ) 5Y13 (X-ray 1.75A ) 6AYL (X-ray 1.86A ) 6LJS (X-ray 1.75A ) 6LJT (X-ray 1.45A ) 6LJU (X-ray 1.50A ) 6LJV (X-ray 1.40A ) 6LJW (X-ray 1.40A ) 6LJX (X-ray 1.75A ) |
| DBSNP | rs1319351179 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P04117}. Nucleus {ECO:0000250|UniProtKB:P04117}. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250|UniProtKB:P04117}. |
| Mouse PG classification | NA |
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