| Gene Information | |
|---|---|
| Gene Name | MPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 635 |
| Protein Names | Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) |
| Target Name | thrombopoietin receptor |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000117400 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P40238 |
| Gene Card | MPL |
| Uniprot ID | P40238 |
| Pfam | PF09067; PF00041 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000093385) |
| Ortholog in Animals | Alpaca_ MPL ( ortholog_one2one ) Dog_ MPL ( ortholog_one2one ) GuineaPig_ MPL ( ortholog_one2one ) Macaque_ MPL ( ortholog_one2one ) Mouse_ Mpl ( ortholog_one2one ) Pig_ MPL ( ortholog_one2one ) Rat_ Mpl ( ortholog_one2one ) Rabbit_ MPL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL4R, IL2RB, IL7R, IL9R, IL21R, CSF2RB, EPOR |
| Tissue | NA |
| Tissue Specificity | Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17292650 rs6087 rs763568293 rs28928907 rs1196161699 rs750046020 rs12731981 rs764904424 rs758428763 rs6088 rs28928908 rs1006158872 rs121913614 rs121913616 rs121913615 rs1448812001 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25538044}; Single-pass type I membrane protein. Golgi apparatus {ECO:0000269|PubMed:25538044}. Cell surface {ECO:0000269|PubMed:25538044}. |
| Mouse PG classification | HPG |
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