| Gene Information | |
|---|---|
| Gene Name | CEP350 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3117 |
| Protein Names | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000135837 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | CEP350 |
| Uniprot ID | Q5VT06 |
| Pfam | PF01302; PF14309 |
| In ASD | no |
| Allosteric Prediction | no (-0.76172121) |
| Ortholog in Animals | Alpaca_ CEP350 ( ortholog_one2one ) Dog_ CEP350 ( ortholog_one2one ) Macaque_ CEP350 ( ortholog_one2one ) Mouse_ Cep350 ( ortholog_one2one ) Pig_ CEP350 ( ortholog_one2one ) Rat_ Cep350 ( ortholog_one2one ) Rabbit_ CEP350 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas. {ECO:0000269|PubMed:11891061, ECO:0000269|PubMed:15615782}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2COZ (NMR - ) |
| DBSNP | rs6692219 rs2477120 rs12125245 rs16855164 rs16855164 rs12124336 rs56173179 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16314388}. Nucleus {ECO:0000269|PubMed:15615782}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28659385}. Note=Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| Mouse PG classification | NA |
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