| Gene Information | |
|---|---|
| Gene Name | NEU3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 428 |
| Protein Names | Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162139 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UQ49 |
| Gene Card | NEU3 |
| Uniprot ID | Q9UQ49 |
| Pfam | PF13088 |
| In ASD | no |
| Allosteric Prediction | no (-0.261881673) |
| Ortholog in Animals | Alpaca_ NEU3 ( ortholog_one2one ) Dog_ NEU3 ( ortholog_one2one ) GuineaPig_ NEU3 ( ortholog_one2one ) Macaque_ NEU3 ( ortholog_one2one ) Mouse_ Neu3 ( ortholog_one2one ) Pig_ NEU3 ( ortholog_one2one ) Rat_ Neu3 ( ortholog_one2one ) Rabbit_ NEU3 ( ortholog_one2one ) |
| Ohnologs | NEU2, NEU4 |
| Paralogs | NEU4, NEU2, NEU1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. {ECO:0000269|PubMed:10861246}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7115499 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:17708748, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}; Peripheral membrane protein {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:17708748}. Membrane, caveola {ECO:0000269|PubMed:12011038}. Early endosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Recycling endosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Lysosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Note=Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). {ECO:0000250|UniProtKB:Q9JMH7, ECO:0000269|PubMed:28646141}. |
| Mouse PG classification | NA |
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