| Gene Information | |
|---|---|
| Gene Name | SLC4A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1241 |
| Protein Names | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000164889 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P04920 |
| Gene Card | SLC4A2 |
| Uniprot ID | P04920 |
| Pfam | PF07565; PF00955 |
| In ASD | no |
| Allosteric Prediction | no (-0.420063169) |
| Ortholog in Animals | Alpaca_ SLC4A2 ( ortholog_one2one ) Dog_ SLC4A2 ( ortholog_one2one ) GuineaPig_ SLC4A2 ( ortholog_one2one ) Macaque_ SLC4A2 ( ortholog_one2one ) Mouse_ Slc4a2 ( ortholog_one2one ) Pig_ SLC4A2 ( ortholog_one2one ) Rat_ Slc4a2 ( ortholog_one2one ) Rabbit_ SLC4A2 ( ortholog_one2one ) |
| Ohnologs | SLC4A1, SLC4A3 |
| Paralogs | SLC4A9, SLC4A3, SLC4A4, SLC4A10, SLC4A5, SLC4A11, SLC4A7, SLC4A1, SLC4A8 |
| Tissue | NA |
| Tissue Specificity | [Isoform A]: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. {ECO:0000269|PubMed:10623603}.; [Isoform B1]: Expressed in the liver and kidney. {ECO:0000269|PubMed:10623603}.; [Isoform B2]: Expressed in the liver and kidney. {ECO:0000269|PubMed:10623603}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2303929 rs2229551 rs35016052 rs34918764 |
| Subcellular location [CC] | [Isoform A]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; [Isoform B1]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; [Isoform B2]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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