Gene Information
Gene NameCYP4A11
OrganismHomo sapiens (Human)
Gene Length519
Protein NamesCytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
Target Namecytochrome p450 4a11
Target TypeNA
Gene Age78 ( ENSG00000187048 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ02928
Gene CardCYP4A11
Uniprot IDQ02928
PfamPF00067
In ASDno
Allosteric Predictionyes (0.660069044)
Ortholog in AnimalsAlpaca_ CYP4A22 ( ortholog_many2many )
Macaque_ CYP4A45 ( ortholog_many2many )
Macaque_ CYP4A11 ( ortholog_many2many )
Mouse_ Cyp4a31 ( ortholog_many2many )
Mouse_ Cyp4a32 ( ortholog_many2many )
Mouse_ Cyp4a10 ( ortholog_many2many )
Mouse_ Cyp4a30b ( ortholog_many2many )
Rat_ Cyp4a1 ( ortholog_many2many )
Rat_ Cyp4a3 ( ortholog_many2many )
OhnologsCYP4F11, CYP4F22, CYP4F2, CYP4F12, CYP4F8, CYP4F3
ParalogsCYP4A22, CYP4F12, CYP4B1, CYP4F8, CYP4F11, CYP19A1, CYP4F2, CYP4F22, CYP4X1, CYP4Z1, CYP4F3, CYP4V2
Tissueliver, kidney
Tissue SpecificityExpressed in liver (PubMed:7679927). Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:7679927}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs12759923  rs3899049  rs1126742 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000305|PubMed:1739747};
Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:1739747};
Peripheral membrane protein {ECO:0000305}.
Mouse PG classificationNA
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