| Gene Information | |
|---|---|
| Gene Name | CENPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 140 |
| Protein Names | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000115163 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P49450 |
| Gene Card | CENPA |
| Uniprot ID | P49450 |
| Pfam | PF00125 |
| In ASD | no |
| Allosteric Prediction | no (-0.445114062) |
| Ortholog in Animals | Alpaca_ CENPA ( ortholog_one2one ) Dog_ CENPA ( ortholog_one2one ) GuineaPig_ CENPA ( ortholog_one2one ) Macaque_ CENPA ( ortholog_one2one ) Mouse_ Cenpa ( ortholog_one2one ) Pig_ CENPA ( ortholog_one2one ) Rat_ Cenpa ( ortholog_one2one ) Rabbit_ CENPA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | H3-7, H3C7, H3C13, H3C2, H3C8, H3C11, H3-4, H3C4, H3C15, H3C10, H3C14, H3C3, H3C1, H3C12, H3C6, H3-3A, H3-5, H3-3B, H3Y1, H3Y2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.003125(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3AN2 (X-ray 3.60A ) 3NQJ (X-ray 2.10A ) 3NQU (X-ray 2.50A ) 3R45 (X-ray 2.60A ) 3WTP (X-ray 2.67A ) 5CVD (X-ray 1.30A ) 5Z23 (X-ray 2.73A ) 6BUZ (EM 3.92A ) 6C0W (EM 4.00A ) 6E0C (EM 2.63A ) 6E0P (EM 2.60A ) 6KDQ (X-ray 1.50A ) 6KDS (X-ray 1.84A ) 6L49 (EM 18.90A ) 6MUO (EM 3.60A ) 6MUP (EM 3.50A ) 6O1D (EM 3.40A ) 6SE0 (EM 3.80A ) 6SE6 (EM 3.50A ) 6SEE (EM 4.20A ) 6SEF (EM 3.70A ) 6SEG (EM 3.10A ) 6TEM (EM 3.90A ) 7D20 (EM 3.00A ) 7PII (EM 2.68A ) 7R5R (EM 2.44A ) 7U46 (EM 2.68A ) 7U47 (EM 7.50A ) 7U4D (EM 8.10A ) 7YWX (EM 12.00A ) 7YYH (EM 8.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:9024683}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:20739937, ECO:0000269|PubMed:21743476, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683}. Note=Localizes exclusively to sites of kinetochore assembly in centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658). {ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:25556658}. |
| Mouse PG classification | NA |
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