| Gene Information | |
|---|---|
| Gene Name | KIAA0558 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1150 |
| Protein Names | Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NY47 |
| Gene Card | CACNA2D2 |
| Uniprot ID | Q9NY47 |
| Pfam | PF08473; PF00092; PF08399 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269|PubMed:10766861, ECO:0000269|PubMed:11687876, ECO:0000269|PubMed:9880589}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35497591 rs1211603072 rs743855 rs587776948 rs1575578837 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}. |
| Mouse PG classification | NA |
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