| Gene Information | |
|---|---|
| Gene Name | DZIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 867 |
| Protein Names | Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134874 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86YF9 |
| Gene Card | DZIP1 |
| Uniprot ID | Q86YF9 |
| Pfam | PF13815 |
| In ASD | no |
| Allosteric Prediction | no (-1.652416947) |
| Ortholog in Animals | Alpaca_ DZIP1 ( ortholog_one2one ) Dog_ DZIP1 ( ortholog_one2one ) GuineaPig_ DZIP1 ( ortholog_one2one ) Macaque_ DZIP1 ( ortholog_one2one ) Mouse_ Dzip1 ( ortholog_one2one ) Pig_ DZIP1 ( ortholog_one2one ) Rat_ Dzip1 ( ortholog_one2many ) Rat_ Dzip1-ps1 ( ortholog_one2many ) Rabbit_ DZIP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RILPL1, DZIP1L, RILPL2, RILP |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in testis (at protein level) (PubMed:15081113, PubMed:32051257). Also expressed in fetal brain, adult oocytes and ovary (PubMed:15081113). Expressed in undifferentiated ES cells (PubMed:15081113). In testis, it is specifically expressed in germ cells (at protein level) (PubMed:15081113, PubMed:32051257). Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes (PubMed:15081113). {ECO:0000269|PubMed:15081113, ECO:0000269|PubMed:32051257}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9561921 rs34303958 rs11070136 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19852954}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:27979967}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19852954}. Nucleus {ECO:0000269|PubMed:15081113}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BMD2}. Cytoplasm {ECO:0000269|PubMed:15081113}. Note=Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (PubMed:19852954). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (By similarity). {ECO:0000250|UniProtKB:Q8BMD2, ECO:0000269|PubMed:19852954}. |
| Mouse PG classification | NA |
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