| Gene Information | |
|---|---|
| Gene Name | RASSF10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Ras association domain-containing protein 10 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000189431 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | A6NK89 |
| Gene Card | RASSF10 |
| Uniprot ID | A6NK89 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.843206328) |
| Ortholog in Animals | Alpaca_ RASSF10 ( ortholog_one2one ) Dog_ RASSF10 ( ortholog_one2one ) GuineaPig_ RASSF10 ( ortholog_one2one ) Macaque_ RASSF10 ( ortholog_one2one ) Mouse_ Rassf10 ( ortholog_one2one ) Pig_ RASSF10 ( ortholog_one2one ) Rat_ Rassf10 ( ortholog_one2one ) Rabbit_ RASSF10 ( ortholog_one2one ) |
| Ohnologs | RASSF9 |
| Paralogs | RASSF9, RASSF8, RASSF7 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas. {ECO:0000269|PubMed:20956940}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs4323847 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20956940}. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm. |
| Mouse PG classification | NA |
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