| Gene Information | |
|---|---|
| Gene Name | RAB35 |
| Organism | Homo sapiens (Human) |
| Gene Length | 201 |
| Protein Names | Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000111737 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15286 |
| Gene Card | RAB35 |
| Uniprot ID | Q15286 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.851667383) |
| Ortholog in Animals | Alpaca_ RAB35 ( ortholog_one2one ) Dog_ RAB35 ( ortholog_one2one ) GuineaPig_ RAB35 ( ortholog_one2one ) Macaque_ RAB35 ( ortholog_one2one ) Mouse_ Rab35 ( ortholog_one2one ) Pig_ RAB35 ( ortholog_one2one ) Rat_ Rab35 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003212(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3TW8 (X-ray 2.10A ) 6EKK (X-ray 1.82A ) 6IF2 (X-ray 2.40A ) 6IF3 (X-ray 1.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:16950109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16950109}. Endosome {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065). {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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