Gene Information
Gene NameBTN3A1
OrganismHomo sapiens (Human)
Gene Length513
Protein NamesButyrophilin subfamily 3 member A1 (CD antigen CD277)
Target NameNA
Target TypeNA
Gene Age36 ( ENSG00000026950 )
Evolutionary StageEumetazoa
AlphaFoldDBO00481
Gene CardBTN3A1
Uniprot IDO00481
PfamPF13765; PF00622; PF07686
In ASDno
Allosteric Predictionno (-1.205915223)
Ortholog in AnimalsAlpaca_ BTN3A1 ( ortholog_one2one )
Macaque_ BTN3A1 ( ortholog_one2one )
Mouse_ Gm36028 ( ortholog_one2one )
Rat_ Gm36028 ( ortholog_one2one )
OhnologsNA
ParalogsBTN2A2, CD276, BTNL2, BTN2A1, BTNL9, ICOSLG, ERMAP, HHLA2, VTCN1, BTN1A1, BTN3A3, BTN3A2, MOG, BTNL3, BTNL8
TissueNA
Tissue SpecificityDetected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle. {ECO:0000269|PubMed:20610803, ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:9149941}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4F80  (X-ray  1.94A  4F9L  (X-ray  3.14A  4F9P  (X-ray  3.52A  4JKW  (X-ray  2.01A  4K55  (X-ray  1.91A  4N7I  (X-ray  1.40A  4N7U  (X-ray  1.46A  4V1P  (X-ray  2.04A  5HM7  (X-ray  1.93A  5LYG  (X-ray  1.60A  5LYK  (X-ray  1.70A  5ZXK  (X-ray  1.96A  6ISM  (X-ray  1.25A  6ITA  (X-ray  1.20A  6J06  (X-ray  2.65A  6XLQ  (X-ray  3.00A 
DBSNP rs56161420  rs1057933  rs41266839  rs4712990 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497};
Single-pass type I membrane protein {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
Mouse PG classificationNA
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