| Gene Information | |
|---|---|
| Gene Name | VNN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000112299 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95497 |
| Gene Card | VNN1 |
| Uniprot ID | O95497 |
| Pfam | PF00795; PF19018 |
| In ASD | no |
| Allosteric Prediction | no (-0.531520758) |
| Ortholog in Animals | Alpaca_ VNN1 ( ortholog_one2one ) Dog_ VNN1 ( ortholog_one2many ) GuineaPig_ VNN1 ( ortholog_one2one ) Macaque_ VNN1 ( ortholog_one2one ) Mouse_ Vnn1 ( ortholog_one2one ) Pig_ VNN1 ( ortholog_one2one ) Rat_ Vnn1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VNN2, BTD |
| Tissue | gall.bladder, kidney, lymph.node, spleen, substantia.nigra, liver, whole.blood |
| Tissue Specificity | Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. {ECO:0000269|PubMed:19322213}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CYF (X-ray 2.25A ) 4CYG (X-ray 2.30A ) 4CYY (X-ray 2.89A ) 7SLV (X-ray 2.13A ) 7SLX (X-ray 2.35A ) 7SLY (X-ray 2.17A ) |
| DBSNP | rs2294757 rs2272996 rs45610032 rs45624336 rs45523444 rs34535050 rs45562238 rs35938565 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:11491533}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Mouse PG classification | NA |
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