Gene Information
Gene NameKIAA0248
OrganismHomo sapiens (Human)
Gene Length1859
Protein NamesGolgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ92538
Gene CardGBF1
Uniprot IDQ92538
PfamPF16213; PF01369; PF12783
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11191274 
Subcellular location [CC]Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12808027}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23386609}. Golgi apparatus {ECO:0000269|PubMed:31519766}. Cytoplasm {ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:31519766}. Lipid droplet {ECO:0000269|PubMed:21789191}. Membrane;
Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes (PubMed:15616190). Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (PubMed:15813748). In neutrophils is translocated from the Golgi to the leading edge upon GPCR stimulation (PubMed:22573891). Localization to lipid droplets is questionable (PubMed:22185782). {ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000305|PubMed:15616190, ECO:0000305|PubMed:15813748}.
Mouse PG classificationNA
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