| Gene Information | |
|---|---|
| Gene Name | CTSG |
| Organism | Homo sapiens (Human) |
| Gene Length | 255 |
| Protein Names | Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form] |
| Target Name | cathepsin g |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100448 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08311 |
| Gene Card | CTSG |
| Uniprot ID | P08311 |
| Pfam | PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (0.960901283) |
| Ortholog in Animals | Alpaca_ CTSG ( ortholog_one2one ) Dog_ CTSG ( ortholog_one2one ) Macaque_ CTSG ( ortholog_one2one ) Mouse_ Ctsg ( ortholog_one2one ) Rat_ Ctsg ( ortholog_one2one ) Rabbit_ CTSG ( ortholog_one2one ) |
| Ohnologs | GZMA |
| Paralogs | GZMB, GZMH, CMA1, AZU1, KLK13, KLK6 |
| Tissue | bone.marrow |
| Tissue Specificity | Expressed in neutrophils (at protein level) (PubMed:3799965). Expressed in B cells (PubMed:15100291). {ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:3799965}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1AU8 (X-ray 1.90A ) 1CGH (X-ray 1.80A ) 1KYN (X-ray 3.50A ) 1T32 (X-ray 1.85A ) 6VTM (X-ray 1.60A ) |
| DBSNP | rs45567233 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:29077095, ECO:0000269|PubMed:8194606}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic granule {ECO:0000269|PubMed:7499346}. Secreted {ECO:0000269|PubMed:29077095, ECO:0000269|PubMed:32144329, ECO:0000269|PubMed:3390156}. Cytoplasm, cytosol {ECO:0000269|PubMed:29077095}. Lysosome {ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:29077095}. Nucleus {ECO:0000269|PubMed:11259672}. Note=Secreted by activated neutrophils (PubMed:3390156). Detected in synovial fluid (PubMed:32144329). Localizes to lysosomes in B cells where it is not endogenously synthesized but is internalized from the cell membrane (PubMed:15100291). Localizes to the nucleus during apoptosis (PubMed:11259672). {ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:32144329, ECO:0000269|PubMed:3390156}. |
| Mouse PG classification | NA |
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