| Gene Information | |
|---|---|
| Gene Name | GPR84 |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33) |
| Target Name | inflammation-related gpcr ex33 |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000139572 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQS5 |
| Gene Card | GPR84 |
| Uniprot ID | Q9NQS5 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.081326355) |
| Ortholog in Animals | Alpaca_ GPR84 ( ortholog_one2one ) Dog_ GPR84 ( ortholog_one2one ) GuineaPig_ GPR84 ( ortholog_one2one ) Macaque_ GPR84 ( ortholog_one2one ) Pig_ GPR84 ( ortholog_one2one ) Rat_ Gpr84 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | appendix, bone.marrow |
| Tissue Specificity | Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes. {ECO:0000269|PubMed:11273702, ECO:0000269|PubMed:11404393, ECO:0000269|PubMed:16966319}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11170883 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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