| Gene Information | |
|---|---|
| Gene Name | IRAK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 712 |
| Protein Names | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) |
| Target Name | interleukin-1 receptor-associated kinase 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000184216 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P51617 |
| Gene Card | IRAK1 |
| Uniprot ID | P51617 |
| Pfam | PF00531; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.835935006) |
| Ortholog in Animals | Alpaca_ IRAK1 ( ortholog_one2many ) Dog_ IRAK1 ( ortholog_one2one ) GuineaPig_ IRAK1 ( ortholog_one2one ) Macaque_ IRAK1 ( ortholog_one2one ) Mouse_ Irak1 ( ortholog_one2one ) Pig_ IRAK1 ( ortholog_one2one ) Rat_ Irak1 ( ortholog_one2one ) Rabbit_ IRAK1 ( ortholog_one2one ) |
| Ohnologs | IRAK3, IRAK2, IRAK4 |
| Paralogs | IRAK4, HASPIN, IRAK3, IRAK2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. {ECO:0000269|PubMed:11397809}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6BFN (X-ray 2.26A ) |
| DBSNP | rs11465830 rs1059702 rs10127175 rs56340948 rs1059703 rs34112487 rs35638718 rs56082801 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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