Gene Information
Gene NameIL27RA
OrganismHomo sapiens (Human)
Gene Length636
Protein NamesInterleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000104998 )
3 ( ENSG00000288185 )
Evolutionary StageMammalia
AlphaFoldDBQ6UWB1
Gene CardIL27RA
Uniprot IDQ6UWB1
PfamPF00041
In ASDno
Allosteric Predictionno (-0.799442528)
Ortholog in AnimalsAlpaca_ IL27RA ( ortholog_one2one )
Dog_ IL27RA ( ortholog_one2one )
GuineaPig_ IL27RA ( ortholog_one2one )
Macaque_ IL27RA ( ortholog_one2one )
Mouse_ Il27ra ( ortholog_one2one )
Pig_ IL27RA ( ortholog_one2one )
Rat_ Il27ra ( ortholog_one2one )
Rabbit_ IL27RA ( ortholog_one2one )
OhnologsNA
ParalogsCRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR
TissueNA
Tissue SpecificityHighly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. {ECO:0000269|PubMed:11057672, ECO:0000269|PubMed:9600072}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7U7N  (EM  3.47A  ) 
DBSNP NA 
Subcellular location [CC]Membrane;
Single-pass type I membrane protein.
Mouse PG classificationNA
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