| Gene Information | |
|---|---|
| Gene Name | SMURF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 748 |
| Protein Names | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000108854 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HAU4 |
| Gene Card | SMURF2 |
| Uniprot ID | Q9HAU4 |
| Pfam | PF00168; PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.201160724) |
| Ortholog in Animals | Alpaca_ SMURF2 ( ortholog_one2one ) Dog_ SMURF2 ( ortholog_one2one ) GuineaPig_ SMURF2 ( ortholog_one2one ) Macaque_ SMURF2 ( ortholog_one2one ) Mouse_ Smurf2 ( ortholog_one2one ) Pig_ SMURF2 ( ortholog_one2one ) Rat_ Smurf2 ( ortholog_one2one ) Rabbit_ SMURF2 ( ortholog_one2one ) |
| Ohnologs | SMURF1 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.053333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZVD (X-ray 2.10A ) 2DJY (NMR - ) 2JQZ (NMR - ) 2KXQ (NMR - ) 2LTZ (NMR - ) 6FX4 (X-ray 2.50A ) 7M3Q (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts. |
| Mouse PG classification | NA |
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