| Gene Information | |
|---|---|
| Gene Name | DDHD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 711 |
| Protein Names | Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (KIAA0725p) (SAM, WWE and DDHD domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000085788 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94830 |
| Gene Card | DDHD2 |
| Uniprot ID | O94830 |
| Pfam | PF02862; PF00536; PF02825 |
| In ASD | no |
| Allosteric Prediction | no (-0.900960704) |
| Ortholog in Animals | Alpaca_ DDHD2 ( ortholog_one2one ) Dog_ BAG4 ( ortholog_one2one ) GuineaPig_ DDHD2 ( ortholog_one2one ) Macaque_ DDHD2 ( ortholog_one2one ) Mouse_ Ddhd2 ( ortholog_one2one ) Pig_ DDHD2 ( ortholog_one2one ) Rat_ Ddhd2 ( ortholog_one2one ) Rabbit_ DDHD2 ( ortholog_one2one ) |
| Ohnologs | SEC23IP |
| Paralogs | DDHD1, SEC23IP |
| Tissue | NA |
| Tissue Specificity | Widely expressed (at protein level). {ECO:0000269|PubMed:11788596}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2306899 rs375168720 |
| Subcellular location [CC] | Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P. |
| Mouse PG classification | LPG |
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