| Gene Information | |
|---|---|
| Gene Name | KIAA0093 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1319 |
| Protein Names | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P46934 |
| Gene Card | NEDD4 |
| Uniprot ID | P46934 |
| Pfam | PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.039455(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2KPZ (NMR - ) 2KQ0 (NMR - ) 2M3O (NMR - ) 2XBB (X-ray 2.68A ) 2XBF (X-ray 2.50A ) 3B7Y (X-ray 1.80A ) 4BBN (X-ray 2.51A ) 4BE8 (X-ray 3.00A ) 4N7F (X-ray 1.10A ) 4N7H (X-ray 1.70A ) 5AHT (NMR - ) 5C7J (X-ray 3.00A ) 5C91 (X-ray 2.44A ) |
| DBSNP | rs1912403 rs2303580 rs2303579 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11342538}. Nucleus {ECO:0000269|PubMed:11342538}. Cell membrane {ECO:0000250|UniProtKB:P46935}; Peripheral membrane protein {ECO:0000250|UniProtKB:P46935}. Note=Predominantly cytoplasmic but also located in the nucleus (PubMed:11342538). Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1 (PubMed:18819914). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:18819914}. |
| Mouse PG classification | NA |
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