Gene Information
Gene NameSLC18B1
OrganismHomo sapiens (Human)
Gene Length456
Protein NamesMFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000146409 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ6NT16
Gene CardSLC18B1
Uniprot IDQ6NT16
PfamPF07690
In ASDno
Allosteric Predictionno (-0.425814427)
Ortholog in AnimalsAlpaca_ SLC18B1 ( ortholog_one2one )
Dog_ SLC18B1 ( ortholog_one2one )
GuineaPig_ SLC18B1 ( ortholog_one2one )
Macaque_ SLC18B1 ( ortholog_one2one )
Mouse_ Slc18b1 ( ortholog_one2one )
Pig_ SLC18B1 ( ortholog_one2one )
Rat_ Slc18b1 ( ortholog_one2one )
Rabbit_ SLC18B1 ( ortholog_one2one )
OhnologsNA
ParalogsSLC18A3, SLC18A2, SLC18A1
TissueNA
Tissue SpecificityExpressed in various tissues including lung, placenta, adrenal gland, liver, testis, and brain. {ECO:0000269|PubMed:25355561}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs59989552  rs41286192  rs6926101 
Subcellular location [CC]Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:D3Z5L6};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4A9K4};
Multi-pass membrane protein {ECO:0000250|UniProtKB:D4A9K4}. Note=Colocalizes with VAMP3 and VAMP8 in mast cell secretory granules, which are distinct from histamine- and serotonin-containing granules (By similarity). Partly colocalizes with SYP in synaptic vesicles in hippocampal neurons. Colocalizes with SYP and VAMP2 in secretory vesicles of astrocytes (By similarity). {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000250|UniProtKB:D4A9K4}.
Mouse PG classificationNA
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