| Gene Information | |
|---|---|
| Gene Name | TIAM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1701 |
| Protein Names | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146426 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IVF5 |
| Gene Card | TIAM2 |
| Uniprot ID | Q8IVF5 |
| Pfam | PF00595; PF00169; PF00621; PF18385 |
| In ASD | no |
| Allosteric Prediction | no (-0.198378268) |
| Ortholog in Animals | Alpaca_ TIAM2 ( ortholog_one2one ) Dog_ TIAM2 ( ortholog_one2one ) GuineaPig_ TIAM2 ( ortholog_one2one ) Macaque_ TIAM2 ( ortholog_one2one ) Mouse_ Tiam2 ( ortholog_one2one ) Pig_ TIAM2 ( ortholog_one2one ) Rat_ Tiam2 ( ortholog_one2one ) |
| Ohnologs | TIAM1 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269|PubMed:10512681}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs931312 rs7770537 rs4259257 rs11751128 rs1571767 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6ZPF3}. Perikaryon {ECO:0000250|UniProtKB:Q6ZPF3}. |
| Mouse PG classification | NA |
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