| Gene Information | |
|---|---|
| Gene Name | ACACB |
| Organism | Homo sapiens (Human) |
| Gene Length | 2458 |
| Protein Names | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) |
| Target Name | acetyl-coa carboxylase 2 |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000076555 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00763 |
| Gene Card | ACACB |
| Uniprot ID | O00763 |
| Pfam | PF08326; PF02785; PF00289; PF00364; PF01039; PF02786 |
| In ASD | yes |
| Allosteric Prediction | yes (1.037990287) |
| Ortholog in Animals | Alpaca_ ACACB ( ortholog_one2one ) Dog_ ACACB ( ortholog_one2one ) GuineaPig_ ACACB ( ortholog_one2one ) Macaque_ ACACB ( ortholog_one2one ) Mouse_ Acacb ( ortholog_one2one ) Pig_ ACACB ( ortholog_one2one ) Rat_ Acacb ( ortholog_one2one ) Rabbit_ ACACB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCCC1, ACACA, PCCA, PC |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759). {ECO:0000269|PubMed:19190759, ECO:0000269|PubMed:9099716}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DN8 (NMR - ) 2HJW (X-ray 2.50A ) 2KCC (NMR - ) 3FF6 (X-ray 3.19A ) 3GID (X-ray 2.30A ) 3GLK (X-ray 2.10A ) 3JRW (X-ray 2.60A ) 3JRX (X-ray 2.50A ) 3TDC (X-ray 2.41A ) 4HQ6 (X-ray 2.70A ) 5KKN (X-ray 2.60A ) |
| DBSNP | rs16940029 rs2300455 rs2075260 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:10677481}. |
| Mouse PG classification | NA |
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