| Gene Information | |
|---|---|
| Gene Name | ANLN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1124 |
| Protein Names | Anillin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000011426 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQW6 |
| Gene Card | ANLN |
| Uniprot ID | Q9NQW6 |
| Pfam | PF08174; PF16018; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.36785948) |
| Ortholog in Animals | Alpaca_ ANLN ( ortholog_one2one ) Dog_ ANLN ( ortholog_one2one ) GuineaPig_ ANLN ( ortholog_one2one ) Macaque_ ANLN ( ortholog_one2one ) Mouse_ Anln ( ortholog_one2one ) Pig_ ANLN ( ortholog_one2one ) Rat_ Anln ( ortholog_one2many ) Rabbit_ ANLN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RTKN2, RTKN |
| Tissue | substantia.nigra, brain, testis, hippocampus |
| Tissue Specificity | Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. {ECO:0000269|PubMed:16203764, ECO:0000269|PubMed:24676636}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Y7B (X-ray 1.90A ) 4XH3 (X-ray 2.10A ) 4XOI (X-ray 2.09A ) |
| DBSNP | rs3735400 rs197367 rs587777741 rs1184529372 |
| Subcellular location [CC] | Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000269|PubMed:23870127}. Cell projection, bleb {ECO:0000269|PubMed:23870127}. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody. |
| Mouse PG classification | NA |
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