| Gene Information | |
|---|---|
| Gene Name | CACNA1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 2313 |
| Protein Names | Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3) |
| Target Name | voltage-dependent r-type calcium channel |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000198216 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q15878 |
| Gene Card | CACNA1E |
| Uniprot ID | Q15878 |
| Pfam | PF08763; PF16905; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (0.724500886) |
| Ortholog in Animals | Alpaca_ CACNA1E ( ortholog_one2one ) Dog_ CACNA1E ( ortholog_one2one ) GuineaPig_ CACNA1E ( ortholog_one2one ) Macaque_ CACNA1E ( ortholog_one2one ) Mouse_ Cacna1e ( ortholog_one2one ) Pig_ CACNA1E ( ortholog_one2one ) Rat_ Cacna1e ( ortholog_one2one ) |
| Ohnologs | CACNA1A, CACNA1B |
| Paralogs | SCN11A, CACNA1C, CATSPER1, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A |
| Tissue | NA |
| Tissue Specificity | Expressed in neuronal tissues and in kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3BXL (X-ray 2.30A ) |
| DBSNP | rs1553286282 rs886039323 rs778291283 rs1361083258 rs869312920 rs12131800 rs12131800 rs35737760 rs1553345844 rs704326 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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