| Gene Information | |
|---|---|
| Gene Name | KHK |
| Organism | Homo sapiens (Human) |
| Gene Length | 298 |
| Protein Names | Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000138030 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P50053 |
| Gene Card | KHK |
| Uniprot ID | P50053 |
| Pfam | PF00294 |
| In ASD | no |
| Allosteric Prediction | no (-0.008520236) |
| Ortholog in Animals | Alpaca_ KHK ( ortholog_one2one ) Dog_ KHK ( ortholog_one2one ) GuineaPig_ KHK ( ortholog_one2one ) Mouse_ Khk ( ortholog_one2one ) Pig_ KHK ( ortholog_one2one ) Rat_ Khk ( ortholog_one2one ) Rabbit_ KHK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBKS, TMEM256, ADK |
| Tissue | duodenum, kidney, liver, small.intestine |
| Tissue Specificity | Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye. {ECO:0000269|PubMed:9799106}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HLZ (X-ray 1.85A ) 2HQQ (X-ray 1.86A ) 2HW1 (X-ray 2.10A ) 3B3L (X-ray 2.90A ) 3NBV (X-ray 2.30A ) 3NBW (X-ray 2.34A ) 3NC2 (X-ray 2.50A ) 3NC9 (X-ray 2.40A ) 3NCA (X-ray 2.60A ) 3Q92 (X-ray 2.80A ) 3QA2 (X-ray 2.52A ) 3QAI (X-ray 2.70A ) 3RO4 (X-ray 2.60A ) 5WBM (X-ray 2.16A ) 5WBO (X-ray 2.25A ) 5WBP (X-ray 2.74A ) 5WBQ (X-ray 2.40A ) 5WBR (X-ray 2.58A ) 5WBZ (X-ray 2.40A ) 6UL7 (X-ray 2.30A ) 6W0N (X-ray 2.41A ) 6W0W (X-ray 2.80A ) 6W0X (X-ray 2.38A ) 6W0Y (X-ray 2.54A ) 6W0Z (X-ray 2.30A ) |
| DBSNP | rs104893643 rs104893644 rs2304681 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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