| Gene Information | |
|---|---|
| Gene Name | KHDC3L |
| Organism | Homo sapiens (Human) |
| Gene Length | 217 |
| Protein Names | KH domain-containing protein 3 (ES cell-associated transcript 1 protein) (KHDC3-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000203908 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q587J8 |
| Gene Card | KHDC3L |
| Uniprot ID | Q587J8 |
| Pfam | PF16005 |
| In ASD | no |
| Allosteric Prediction | no (-1.470928389) |
| Ortholog in Animals | Alpaca_ KHDC3L ( ortholog_one2many ) Macaque_ KHDC3L ( ortholog_one2one ) Mouse_ Khdc3 ( ortholog_one2one ) Rat_ Khdc3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OOEP |
| Tissue | NA |
| Tissue Specificity | Expression appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition. {ECO:0000269|PubMed:21885028}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs144291287 rs564533 rs561930 |
| Subcellular location [CC] | Cytoplasm, cell cortex {ECO:0000269|PubMed:25542835}. Nucleus {ECO:0000269|PubMed:25542835, ECO:0000269|PubMed:31609975}. Mitochondrion {ECO:0000250|UniProtKB:Q9CWU5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9CWU5}. Chromosome {ECO:0000269|PubMed:31609975}. Note=Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (PubMed:31609975). {ECO:0000250|UniProtKB:Q9CWU5, ECO:0000269|PubMed:31609975}. |
| Mouse PG classification | NA |
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