| Gene Information | |
|---|---|
| Gene Name | VAMP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 100 |
| Protein Names | Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000118640 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BV40 |
| Gene Card | VAMP8 |
| Uniprot ID | Q9BV40 |
| Pfam | PF00957 |
| In ASD | no |
| Allosteric Prediction | no (-0.426944543) |
| Ortholog in Animals | Dog_ VAMP8 ( ortholog_one2many ) GuineaPig_ VAMP8 ( ortholog_one2one ) Macaque_ VAMP8 ( ortholog_one2one ) Mouse_ Vamp8 ( ortholog_one2one ) Pig_ VAMP8 ( ortholog_one2one ) Rat_ Vamp8 ( ortholog_one2one ) Rabbit_ VAMP8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VAMP2, SEC22A, VAMP7, VAMP3, VAMP4, VAMP1, SEC22C, VAMP5, SEC22B, YKT6 |
| Tissue | NA |
| Tissue Specificity | Platelets. {ECO:0000269|PubMed:12130530}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.016(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4WY4 (X-ray 1.40A ) 7BV6 (X-ray 3.05A ) |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:25686604}; Single-pass type IV membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:9614193}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:25648148}; Single-pass type IV membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Zymogen granule membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250|UniProtKB:Q9WUF4}. |
| Mouse PG classification | NA |
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