| Gene Information | |
|---|---|
| Gene Name | KEAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 624 |
| Protein Names | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) |
| Target Name | kelch-like ech-associated protein 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000079999 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14145 |
| Gene Card | KEAP1 |
| Uniprot ID | Q14145 |
| Pfam | PF07707; PF00651; PF01344 |
| In ASD | no |
| Allosteric Prediction | no (-0.065015693) |
| Ortholog in Animals | Alpaca_ KEAP1 ( ortholog_one2one ) Dog_ KEAP1 ( ortholog_one2one ) GuineaPig_ KEAP1 ( ortholog_one2one ) Macaque_ KEAP1 ( ortholog_one2one ) Mouse_ Keap1 ( ortholog_one2one ) Pig_ KEAP1 ( ortholog_one2one ) Rat_ Keap1 ( ortholog_one2one ) Rabbit_ KEAP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLHL40, KLHDC7B, GAN, BACH1, KLHL20, KLHL10, KLHL42, KLHL21, KLHL32, KBTBD7, KBTBD6, BACH2, KLHL30, KLHL15, KLHL38, KLHL41, KLHL26, KLHL17, KBTBD3, KLHL13, KLHL9, KLHL18, KLHL23, KLHDC7A, KLHL31, IVNS1ABP, KLHL1, KLHL8, KLHL2, KLHL29, KBTBD12, KLHL34, KLHL7, KLHL33, KLHL36, KLHL28, KBTBD11, KLHL14, CCIN, BTBD18, IPP, KLHDC8B, KLHL6, KLHL24, KLHL5, KBTBD13, KBTBD8, KLHL3, KLHL35, KLHL22, KBTBD2, KLHL12, KLHL4, KLHDC8A |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U6D (X-ray 1.85A ) 1ZGK (X-ray 1.35A ) 2FLU (X-ray 1.50A ) 3VNG (X-ray 2.10A ) 3VNH (X-ray 2.10A ) 3ZGC (X-ray 2.20A ) 3ZGD (X-ray 1.98A ) 4CXI (X-ray 2.35A ) 4CXJ (X-ray 2.80A ) 4CXT (X-ray 2.66A ) 4IFJ (X-ray 1.80A ) 4IFL (X-ray 1.80A ) 4IFN (X-ray 2.40A ) 4IN4 (X-ray 2.59A ) 4IQK (X-ray 1.97A ) 4L7B (X-ray 2.41A ) 4L7C (X-ray 2.40A ) 4L7D (X-ray 2.25A ) 4N1B (X-ray 2.55A ) 4XMB (X-ray 2.43A ) 5DAD (X-ray 2.61A ) 5DAF (X-ray 2.37A ) 5F72 (X-ray 1.85A ) 5GIT (X-ray 2.19A ) 5NLB (X-ray 3.45A ) 5WFL (X-ray 1.93A ) 5WFV (X-ray 1.91A ) 5WG1 (X-ray 2.02A ) 5WHL (X-ray 2.50A ) 5WHO (X-ray 2.23A ) 5WIY (X-ray 2.23A ) 5X54 (X-ray 2.30A ) 6FFM (X-ray 2.20A ) 6FMP (X-ray 2.92A ) 6FMQ (X-ray 2.10A ) 6HWS (X-ray 1.75A ) 6LRZ (X-ray 1.54A ) 6ROG (X-ray 2.16A ) 6SP1 (X-ray 2.57A ) 6SP4 (X-ray 2.59A ) 6T7V (X-ray 2.60A ) 6T7Z (X-ray 2.00A ) 6TG8 (X-ray 2.75A ) 6TYM (X-ray 1.42A ) 6TYP (X-ray 2.50A ) 6UF0 (X-ray 1.96A ) 6V6Z (X-ray 1.60A ) 6W66 (X-ray 3.21A ) 6W67 (X-ray 2.20A ) 6W68 (X-ray 2.55A ) 6W69 (X-ray 2.50A ) 6WCQ (EM 8.50A ) 6Z6A (X-ray 2.37A ) 7EXI (X-ray 1.82A ) 7K28 (X-ray 2.15A ) 7K29 (X-ray 2.20A ) 7K2A (X-ray 1.90A ) 7K2B (X-ray 2.31A ) 7K2C (X-ray 2.11A ) 7K2D (X-ray 2.21A ) 7K2E (X-ray 2.03A ) 7K2F (X-ray 2.37A ) 7K2G (X-ray 2.15A ) 7K2H (X-ray 2.09A ) 7K2I (X-ray 2.42A ) 7K2J (X-ray 2.52A ) 7K2K (X-ray 1.98A ) 7K2L (X-ray 1.98A ) 7K2M (X-ray 2.02A ) 7K2N (X-ray 2.22A ) 7K2O (X-ray 2.11A ) 7K2P (X-ray 2.11A ) 7K2Q (X-ray 2.37A ) 7K2R (X-ray 2.10A ) 7K2S (X-ray 2.13A ) 7Q5H (X-ray 2.31A ) 7Q6Q (X-ray 2.55A ) 7Q6S (X-ray 2.14A ) 7Q8R (X-ray 2.28A ) 7Q96 (X-ray 2.42A ) 7XM2 (X-ray 2.30A ) 7XM3 (X-ray 2.80A ) 7XM4 (X-ray 2.70A ) 7XM5 (X-ray 2.40A ) |
| DBSNP | rs1048289 rs777308626 rs1397945617 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15657435, ECO:0000269|PubMed:19424503}. Nucleus {ECO:0000269|PubMed:15657435}. Note=Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972). {ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:20452972}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |