| Gene Information | |
|---|---|
| Gene Name | KDSR |
| Organism | Homo sapiens (Human) |
| Gene Length | 332 |
| Protein Names | 3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000119537 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q06136 |
| Gene Card | KDSR |
| Uniprot ID | Q06136 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.635407757) |
| Ortholog in Animals | Alpaca_ KDSR ( ortholog_one2one ) Dog_ KDSR ( ortholog_one2one ) GuineaPig_ KDSR ( ortholog_one2one ) Macaque_ KDSR ( ortholog_one2one ) Mouse_ Kdsr ( ortholog_one2one ) Pig_ KDSR ( ortholog_one2one ) Rat_ Kdsr ( ortholog_one2one ) Rabbit_ KDSR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHRSX, DHRS13, RDH13, RDH14 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1114167452 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15328338}; Multi-pass membrane protein {ECO:0000269|PubMed:15328338}. |
| Mouse PG classification | NA |
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