| Gene Information | |
|---|---|
| Gene Name | KDR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1356 |
| Protein Names | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) |
| Target Name | vascular endothelial growth factor receptor 2 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000128052 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P35968 |
| Gene Card | KDR |
| Uniprot ID | P35968 |
| Pfam | PF07679; PF07714; PF17988 |
| In ASD | yes |
| Allosteric Prediction | yes (1.15253983) |
| Ortholog in Animals | Alpaca_ KDR ( ortholog_one2one ) Dog_ KDR ( ortholog_one2one ) GuineaPig_ KDR ( ortholog_one2one ) Macaque_ KDR ( ortholog_one2one ) Mouse_ Kdr ( ortholog_one2one ) Pig_ KDR ( ortholog_one2one ) Rat_ Kdr ( ortholog_one2one ) Rabbit_ KDR ( ortholog_one2one ) |
| Ohnologs | FLT4, FLT1, CSF1R |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002768(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1VR2 (X-ray 2.40A ) 1Y6A (X-ray 2.10A ) 1Y6B (X-ray 2.10A ) 1YWN (X-ray 1.71A ) 2M59 (NMR - ) 2MET (NMR - ) 2MEU (NMR - ) 2OH4 (X-ray 2.05A ) 2P2H (X-ray 1.95A ) 2P2I (X-ray 2.40A ) 2QU5 (X-ray 2.95A ) 2QU6 (X-ray 2.10A ) 2RL5 (X-ray 2.65A ) 2X1W (X-ray 2.70A ) 2X1X (X-ray 3.10A ) 2XIR (X-ray 1.50A ) 3B8Q (X-ray 2.75A ) 3B8R (X-ray 2.70A ) 3BE2 (X-ray 1.75A ) 3C7Q (X-ray 2.10A ) 3CJF (X-ray 2.15A ) 3CJG (X-ray 2.25A ) 3CP9 (X-ray 2.50A ) 3CPB (X-ray 2.70A ) 3CPC (X-ray 2.40A ) 3DTW (X-ray 2.90A ) 3EFL (X-ray 2.20A ) 3EWH (X-ray 1.60A ) 3KVQ (X-ray 2.70A ) 3S35 (X-ray 2.20A ) 3S36 (X-ray 3.20A ) 3S37 (X-ray 2.70A ) 3U6J (X-ray 2.15A ) 3V2A (X-ray 3.20A ) 3V6B (X-ray 3.20A ) 3VHE (X-ray 1.55A ) 3VHK (X-ray 2.49A ) 3VID (X-ray 2.30A ) 3VNT (X-ray 1.64A ) 3VO3 (X-ray 1.52A ) 3WZD (X-ray 1.57A ) 3WZE (X-ray 1.90A ) 4AG8 (X-ray 1.95A ) 4AGC (X-ray 2.00A ) 4AGD (X-ray 2.81A ) 4ASD (X-ray 2.03A ) 4ASE (X-ray 1.83A ) 5EW3 (X-ray 2.50A ) 5OYJ (X-ray 2.38A ) 6GQO (X-ray 1.87A ) 6GQP (X-ray 2.09A ) 6GQQ (X-ray 1.52A ) 6XVJ (X-ray 1.78A ) 6XVK (X-ray 1.99A ) |
| DBSNP | rs35636987 rs2305948 rs56286620 rs1870377 rs34231037 rs55716939 rs34038364 rs35603373 rs1139776 rs13129474 rs56302315 rs121917766 |
| Subcellular location [CC] | Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Cell membrane {ECO:0000269|PubMed:25825981}. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269|PubMed:23529610}.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted {ECO:0000305}.; [Isoform 3]: Secreted. |
| Mouse PG classification | NA |
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