| Gene Information | |
|---|---|
| Gene Name | KDM8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 416 |
| Protein Names | Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000155666 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8N371 |
| Gene Card | KDM8 |
| Uniprot ID | Q8N371 |
| Pfam | PF13621 |
| In ASD | no |
| Allosteric Prediction | no (-0.701262642) |
| Ortholog in Animals | Alpaca_ KDM8 ( ortholog_one2one ) Dog_ KDM8 ( ortholog_one2one ) GuineaPig_ KDM8 ( ortholog_one2one ) Macaque_ KDM8 ( ortholog_one2one ) Mouse_ Kdm8 ( ortholog_one2one ) Pig_ KDM8 ( ortholog_one2one ) Rat_ Kdm8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | JMJD7, TYW5, HIF1AN, HSPBAP1 |
| Tissue | duodenum, liver, small.intestine |
| Tissue Specificity | Weakly expressed in most cells. Highly expressed in breast cancer cells (PubMed:20457893). Expressed in embryonic stem cells (PubMed:24740926). {ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24740926}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.085714(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3UYJ (X-ray 2.35A ) 4AAP (X-ray 2.60A ) 4GAZ (X-ray 2.81A ) 4GJY (X-ray 1.25A ) 4GJZ (X-ray 1.05A ) 4QU1 (X-ray 1.57A ) 5FBJ (X-ray 2.42A ) 6AVS (X-ray 2.02A ) 6AX3 (X-ray 2.25A ) 6F4M (X-ray 1.71A ) 6F4N (X-ray 2.54A ) 6F4O (X-ray 1.28A ) 6F4P (X-ray 1.45A ) 6F4Q (X-ray 1.12A ) 6F4R (X-ray 1.30A ) 6F4S (X-ray 1.46A ) 6F4T (X-ray 1.22A ) 6I9L (X-ray 1.53A ) 6I9M (X-ray 1.65A ) 6I9N (X-ray 1.36A ) 7DYT (X-ray 1.62A ) 7DYU (X-ray 1.72A ) 7DYV (X-ray 1.92A ) 7DYW (X-ray 2.13A ) 7DYX (X-ray 2.27A ) |
| DBSNP | rs34445573 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:28982940}. Chromosome {ECO:0000269|PubMed:24981860}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:24981860}. |
| Mouse PG classification | NA |
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