| Gene Information | |
|---|---|
| Gene Name | KDM5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1690 |
| Protein Names | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000073614 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P29375 |
| Gene Card | KDM5A |
| Uniprot ID | P29375 |
| Pfam | PF01388; PF02373; PF02375; PF00628; PF08429; PF02928 |
| In ASD | yes |
| Allosteric Prediction | yes (0.094843231) |
| Ortholog in Animals | Alpaca_ KDM5A ( ortholog_one2one ) Dog_ KDM5A ( ortholog_one2one ) GuineaPig_ KDM5A ( ortholog_one2one ) Macaque_ KDM5A ( ortholog_one2one ) Mouse_ Kdm5a ( ortholog_one2one ) Pig_ KDM5A ( ortholog_one2one ) Rat_ Kdm5a ( ortholog_one2one ) Rabbit_ KDM5A ( ortholog_one2one ) |
| Ohnologs | KDM5C, KDM5B |
| Paralogs | JARID2, KDM4C, KDM4F, KDM4E, KDM4B, KDM4D, KDM5B, KDM5C, KDM5D, KDM4A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JXJ (NMR - ) 2KGG (NMR - ) 2KGI (NMR - ) 3GL6 (X-ray 1.90A ) 5C11 (X-ray 2.80A ) 5CEH (X-ray 3.14A ) 5E6H (X-ray 2.24A ) 5ISL (X-ray 1.69A ) 5IVB (X-ray 1.39A ) 5IVC (X-ray 1.57A ) 5IVE (X-ray 1.78A ) 5IVF (X-ray 1.68A ) 5IVJ (X-ray 1.57A ) 5IVV (X-ray 1.85A ) 5IVY (X-ray 1.45A ) 5IW0 (X-ray 1.63A ) 5IWF (X-ray 2.29A ) 5K4L (X-ray 3.18A ) 5V9P (X-ray 3.00A ) 5V9T (X-ray 3.05A ) 6BGU (X-ray 1.68A ) 6BGV (X-ray 1.59A ) 6BGW (X-ray 1.64A ) 6BGX (X-ray 1.88A ) 6BGY (X-ray 1.22A ) 6BGZ (X-ray 1.69A ) 6BH0 (X-ray 1.99A ) 6BH1 (X-ray 1.93A ) 6BH2 (X-ray 1.45A ) 6BH3 (X-ray 1.70A ) 6BH4 (X-ray 2.05A ) 6BH5 (X-ray 1.65A ) 6DQ4 (X-ray 1.39A ) 6DQ5 (X-ray 1.89A ) 6DQ6 (X-ray 1.59A ) 6DQ7 (X-ray 1.85A ) 6DQ8 (X-ray 1.46A ) 6DQ9 (X-ray 1.75A ) 6DQA (X-ray 1.89A ) 6DQB (X-ray 1.79A ) 6DQC (X-ray 1.75A ) 6DQD (X-ray 1.99A ) 6DQE (X-ray 1.69A ) 6DQF (X-ray 1.69A ) 7KLO (NMR - ) 7KLR (NMR - ) |
| DBSNP | rs11062385 rs2229353 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:7935440}. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9}. |
| Mouse PG classification | NA |
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